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An animal model study showed that spironolactone alleviated liver damage and portal hypertension by reducing intrahepatic resistance[56]
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In this setting, Cys2 is known to increase the activity of betaine-homocysteine methyltransferase-this is the so-called Cys2-sparing effect of Met, which is readily observed when Cys2 is added to a low-Met diet in animal models (20)
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