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Despite the deletion of VEGFR3 in the GFP + ECs in Flt4 i Esm1 KO samples, these results reflect that the villus apex is not entirely composed of Esm1-CreERT2 -targeted ECs, so that only a subset of ECs in the villus apex loses VEGFR3 (Supplementary Fig

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The other key property of ascorbate is its ability to form complexes with, and reduce, higher oxidation states of transition metal ions such as Fe 3+ and Cu 2+