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28,29 Thus, hepatocytes are a versatile in vitro system that can be utilized to conduct a range of ADME and toxicity assays, including clearance prediction, 30,31 transporter-mediated uptake, 31,32 drug–drug interaction potential, 33 enzyme and xenobiotic transporter induction, 34–36 biliary clearance or toxicity, 28,29,37 and hepatotoxicity