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Bromelain is also present in other parts of the pineapple and is found in association with other cysteine proteases ( Figure 1 ) ( Figure 1 2 Review methodology To carry out this updated review on the anticancer effects of bromelain, published studies were searched in specialized databases such as PubMed/MedLine, TRIP database, GeenMedical, Scopus, Web of Science and Google Scholar, using the next MeSH terms: ‘Animals”, “Anticarcinogenic Agents/pharmacology”, “Antineoplastic Agents/pharmacology”, “Bromelain/pharmacology”, “Bromelain/administration and dosage”, “Bromelain/chemistry”, “Cell Line, Tumor”, “Cell Survival/drug effects”, “Dose-Response Relationship”, “Drug, Humans”, “Nanocapsules/administration and dosage”, “Neoplasms/drug therapy”, “Neoplasms, Experimental/pathology”, “Signal Transduction/drug effects”, “Treatment Outcome”
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